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finite element method (fem)-based two-dimensional (2d) model  (COMSOL Inc)

 
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    COMSOL Inc finite element method (fem)-based two-dimensional (2d) model
    Finite Element Method (Fem) Based Two Dimensional (2d) Model, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/finite element method (fem)-based two-dimensional (2d) model/product/COMSOL Inc
    Average 90 stars, based on 1 article reviews
    finite element method (fem)-based two-dimensional (2d) model - by Bioz Stars, 2026-05
    90/100 stars

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    In experimental module, non-resistant and temozolomide (TMZ)-resistant human glioblastoma (hGB) cells were tumoroid-cultured using self-filling microwell arrays (SFMAs). After four days, allowing to form a compact solid tumor structure, tumoroids were co-cultured with NPC-differentiated neurons in a hydrogel matrix within a microfluidic chip. The growth and invasion of tumoroids were monitored over 7 days and were quantified via ImageJ. In the HDC framework, non-resistant and TMZ-resistant cells were two-dimensional (2D) cultured, their metabolic rates were extracted and input to the model, and predictions were validated by comparing with the experimental data. Created with BioRender.com.

    Journal: Communications Engineering

    Article Title: Insights from a multiscale framework on metabolic rate variation driving glioblastoma multiforme growth and invasion

    doi: 10.1038/s44172-024-00319-9

    Figure Lengend Snippet: In experimental module, non-resistant and temozolomide (TMZ)-resistant human glioblastoma (hGB) cells were tumoroid-cultured using self-filling microwell arrays (SFMAs). After four days, allowing to form a compact solid tumor structure, tumoroids were co-cultured with NPC-differentiated neurons in a hydrogel matrix within a microfluidic chip. The growth and invasion of tumoroids were monitored over 7 days and were quantified via ImageJ. In the HDC framework, non-resistant and TMZ-resistant cells were two-dimensional (2D) cultured, their metabolic rates were extracted and input to the model, and predictions were validated by comparing with the experimental data. Created with BioRender.com.

    Article Snippet: Here, we report on a hybrid discrete-continuum (HDC) mathematical framework that uses metabolic data from a biomimetic two-dimensional (2D) in-vitro cancer model to predict three-dimensional (3D) behaviour of in-vitro human glioblastoma (hGB).

    Techniques: Cell Culture